Design and integrity of deterministic system architectures.

Architectures represented by system construction 'building block' components and interrelationships provide the structural form. This thesis addresses processes, procedures and methods that support system design synthesis and specifically the determination of the integrity of candidate architectural structures. Particular emphasis is given to the structural representation of system architectures, their consistency and functional quantification. It is a design imperative that a hierarchically decomposed structure maintains compatibility and consistency between the functional and realisation solutions. Complex systems are normally simplified by the use of hierarchical decomposition so that lower level components are precisely defined and simpler than higher-level components. To enable such systems to be reconstructed from their components, the hierarchical construction must provide vertical intra-relationship consistency, horizontal interrelationship consistency, and inter-component functional consistency. Firstly, a modified process design model is proposed that incorporates the generic structural representation of system architectures. Secondly, a system architecture design knowledge domain is proposed that enables viewpoint evaluations to be aggregated into a coherent set of domains that are both necessary and sufficient to determine the integrity of system architectures. Thirdly, four methods of structural analysis are proposed to assure the integrity of the architecture. The first enables the structural compatibility between the 'building blocks' that provide the emergent functional properties and implementation solution properties to be determined. The second enables the compatibility of the functional causality structure and the implementation causality structure to be determined. The third method provides a graphical representation of architectural structures. The fourth method uses the graphical form of structural representation to provide a technique that enables quantitative estimation of performance estimates of emergent properties for large scale or complex architectural structures. These methods have been combined into a procedure of formal design. This is a design process that, if rigorously executed, meets the requirements for reconstructability

System Resource Sharing for Synchronous Collaboration

We describe problems associated with accessing data resources external to the application, which we term externalities, in replicated synchronous collaborative applications (e.g., a multiuser text editor). Accessing externalities such as les, databases, network connections, environment variables and the system clock is not as straightforward in replicated collaborative software as in single-user applications and centralized collaborative systems. We describe ad hoc solutions that have been used previously. Our primary objection to the ad hoc solutions is that the developer must program dierent behavior into the dierent replicas of a multi-user application, which increases the cost and complexity of development. We introduce a novel general approach to accessing externalities uniformly in a replicated collaborative system. The approach uses a semi-replicated architecture where the actual externality resides at a single location and is accessed via replicated proxies. The proxies multiplex input to and output from the single instance of the externality. This approach facilitates the creation of replicated synchronous groupware in two ways: (1) developers use the same mechanisms as in traditional single-user applications (2) developers program all replicas to execute the same behavior. We describe a general design for proxied access to read{only, write{only and read{write externalities. We discuss the tradeos of this semi- replicated approach over full, literal replication and the class of applications to which this approach can be successfully applied. We also describe details of a prototype implementation of this approach within a replicated collaboration-transparency system, called Flexible JAMM (Java Applets Made Multi-user)

Are we teaching our students what they need to know about ageing? Results from the National Survey of Undergraduate Teaching in Ageing and Geriatric Medicine

Introduction - Learning about ageing and the appropriate management of older patients is important for all doctors. This survey set out to evaluate what medical undergraduates in the UK are taught about ageing and geriatric medicine and how this teaching is delivered. Methods – An electronic questionnaire was developed and sent to the 28/31 UK medical schools which agreed to participate. Results – Full responses were received from 17 schools. 8/21 learning objectives were recorded as taught, and none were examined, across every school surveyed. Elder abuse and terminology and classification of health were taught in only 8/17 and 2/17 schools respectively. Pressure ulcers were taught about in 14/17 schools but taught formally in only 7 of these and examined in only 9. With regard to bio- and socio- gerontology, only 9/17 schools reported teaching in social ageing, 7/17 in cellular ageing and 9/17 in the physiology of ageing. Discussion – Even allowing for the suboptimal response rate, this study presents significant cause for concern with UK undergraduate education related to ageing. The failure to teach comprehensively on elder abuse and pressure sores, in particular, may be significantly to the detriment of older patients

Activity of commercial detergents against conidia and chlamydospores of fusarium oxysporum f. sp. vasinfectum

Current containment recommendations for limiting the spread of race 4 of Fusarium oxysporum f. sp. vasinfectum in California lack non-corrosive yet effective alternatives to bleach for sanitizing equipment used in farming operations. To find an equivalent to Farmcleanse, an Australian product recommended for disinfecting equipment contaminated with the Fusarium wilt pathogen, 26 cleansers and degreasers commercially available in the United States were tested for their ability to kill spores of race 4 of F. oxysporum f. sp. vasinfectum. All treatments were tested at 1:10 and 1:100 (v/v) aqueous dilutions against conidia and chlamydospores in suspension. All treatments were also tested against chlamydospores in soil at a 1:10 dilution. Treatments demonstrating strong anti-fungal activity against spore suspensions at a 1:100 dilution were tested against conidia and chlamydospores at increasing aqueous dilutions (up to 1:100,000). Six products (Clorox, Simple Green d Pro 3, Trewax Nature's Orange, Formula 409 Antibacterial All Purpose Cleaner, Formula 409 Orange Cleaner Degreaser, and Lysol Antibacterial Kitchen Cleaner Citrus Scent) were effective against conidia and chlamydospores at a 1:100 dilution. Two products (Simple Green d Pro 3, Trewax Nature's Orange) gave results similar to bleach at dilutions up to 1:1000 on both conidia and chlamydospores in suspension. Quaternary ammonium compounds were present in four of the six most effective products. None of the cleansers performed as well as bleach against chlamydospores in soil. These results reveal useful alternatives to bleach, but similarity in brand names of distinctly different products should benoted. The results also point to the importance of completely removing soil from equipment prior to spraying with anti-fungal cleansers. © The Cotton Foundation 2011

The botany of the Cunene-Zambezi expedition with notes on Hugo Baum (1867-1950)

WOS:000275977600005 (Nº de Acesso Web of Science)A record and discussion of the Cunene-Zambezi Expedition that took place in Angola from 1899 to 1900 is provided. Although the main aim of the expedition was to evaluate the economic potential of southern Angola, it also resulted in significant botanical collections made by Hugo Baum (1867-1950), many of which serve as holotypes of names of plants from the region, and beyond. The itinerary is supplemented by a map illustrating the route followed by the expedition, and locality names are clarified and updated. A full list of the type specimens of flowering plants is provided, with their nomenclature updated and an indication of where known duplicates are housed

Does the presence of connective tissue disease modify survival in patients with pulmonary fibrosis?

SummaryObjectivesPrevious studies into the survival differences between individuals with idiopathic pulmonary fibrosis and those with connective tissue disease associated pulmonary fibrosis (CTD-PF) have yielded mixed results. The aim of this study is to compare the survival of individuals with CTD-PF to those with idiopathic pulmonary fibrosis clinical syndrome (IPF-CS) using data derived from The Health Improvement network, a large primary care database in the UK.MethodsIncident cases of CTD-PF and IPF-CS between the years 2000–2009 were identified. Survival analysis was performed using Kaplan–Meier methods, stratified by type of connective tissue disease. Cox regression was then used to compare mortality rates between the groups, adjusting for age, gender and year of diagnosis.ResultsA total of 324 cases of CTD-PF and 2209 cases of IPF-CS were followed up over a mean period of 2.3 years. During this period, 113 (34.9%) cases of CTD-PF and 1073 (48.6%) cases of IPF-CS died. The mortality rates for cases with CTD-PF and IPF-CS were 123.6 per 1000 person years (95%CI: 102.8–148.9) and 229.8 per 1000 person years (95% CI: 216.4–244.0) respectively. After adjusting for age, sex and year of diagnosis, cases with CTD-PF had a better prognosis compared to those with IPF-CS (HR 0.76,95%CI: 0.62–0.92).ConclusionThe prognosis of individuals with CTD-PF appears to be significantly better than those with IPF-CS, but remains an important cause of death in patients with connective tissue disease, and requires more effective treatment options

Revisiting the 40Ar/39Ar Chronology of Lunar Meteorite NWA 773 Provides New Constraints on its Diachronous Geologic History

No abstract available

Defensive alliances in spatial models of cyclical population interactions

As a generalization of the 3-strategy Rock-Scissors-Paper game dynamics in space, cyclical interaction models of six mutating species are studied on a square lattice, in which each species is supposed to have two dominant, two subordinated and a neutral interacting partner. Depending on their interaction topologies, these systems can be classified into four (isomorphic) groups exhibiting significantly different behaviors as a function of mutation rate. On three out of four cases three (or four) species form defensive alliances which maintain themselves in a self-organizing polydomain structure via cyclic invasions. Varying the mutation rate this mechanism results in an ordering phenomenon analogous to that of magnetic Ising model.Comment: 4 pages, 3 figure

A methodology for determining amino-acid substitution matrices from set covers

We introduce a new methodology for the determination of amino-acid substitution matrices for use in the alignment of proteins. The new methodology is based on a pre-existing set cover on the set of residues and on the undirected graph that describes residue exchangeability given the set cover. For fixed functional forms indicating how to obtain edge weights from the set cover and, after that, substitution-matrix elements from weighted distances on the graph, the resulting substitution matrix can be checked for performance against some known set of reference alignments and for given gap costs. Finding the appropriate functional forms and gap costs can then be formulated as an optimization problem that seeks to maximize the performance of the substitution matrix on the reference alignment set. We give computational results on the BAliBASE suite using a genetic algorithm for optimization. Our results indicate that it is possible to obtain substitution matrices whose performance is either comparable to or surpasses that of several others, depending on the particular scenario under consideration

Phase transition in a spatial Lotka-Volterra model

Spatial evolution is investigated in a simulated system of nine competing and mutating bacterium strains, which mimics the biochemical war among bacteria capable of producing two different bacteriocins (toxins) at most. Random sequential dynamics on a square lattice is governed by very symmetrical transition rules for neighborhood invasion of sensitive strains by killers, killers by resistants, and resistants by by sensitives. The community of the nine possible toxicity/resistance types undergoes a critical phase transition as the uniform transmutation rates between the types decreases below a critical value $P_c$ above which all the nine types of strain coexist with equal frequencies. Passing the critical mutation rate from above, the system collapses into one of the three topologically identical states, each consisting of three strain types. Of the three final states each accrues with equal probability and all three maintain themselves in a self-organizing polydomain structure via cyclic invasions. Our Monte Carlo simulations support that this symmetry breaking transition belongs to the universality class of the three-state Potts model.Comment: 4 page